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{{ArtBy|autore=Gianni Frisardi}}
    <h2>Abstract</h2>'''Rethinking Mastication: A Neurofunctional Model for the 21st Century'''

The human masticatory system—long regarded as a biomechanical structure composed of teeth, bones, and muscles—is now emerging as a complex adaptive system. Influenced by both anatomical architecture and neurophysiological modulation, chewing is not simply a mechanical act, but a dynamic behavior shaped by cortical and peripheral interactions.

This shift aligns with Thomas Kuhn’s theory of scientific paradigm shifts: when traditional models fail to explain observed anomalies, new frameworks must arise. In dentistry—especially in gnathology, prosthodontics, and orthodontics—classical biomechanics increasingly fails to account for puzzling clinical findings. One of the most striking is functional symmetry in patients with clear occlusal asymmetries.